1. Study suggests many cancer survivors are living with PTSD

    November 29, 2017 by Ashley

    From the Wiley press release:

    A recent study showed approximately one-fifth of patients with cancer experienced post-traumatic stress disorder (PTSD) several months after diagnosis, and many of these patients continued to live with PTSD years later. Published early online in CANCER, a peer-reviewed journal of the American Cancer Society, the findings highlight the need for early identification, careful monitoring, and treatment of PTSD in cancer survivors.

    Although PTSD is primarily known to develop in individuals following a traumatic event such as a serious accident or natural disaster, it can also occur in patients diagnosed with cancer. Because PTSD in cancer has not been explored thoroughly, Caryn Mei Hsien Chan, PhD, of the National University of Malaysia, and her colleagues studied 469 adults with various cancer types within one month of diagnosis at a single oncology referral center. Patients underwent additional testing after six months and again after four years.

    Clinical evaluations revealed a PTSD incidence of 21.7% at 6-months follow-up, with rates dropping to 6.1% at 4-years follow-up. Although overall rates of PTSD decreased with time, roughly one-third of patients initially diagnosed with PTSD were found to have persistent or worsening symptoms four years later.

    “Many cancer patients believe they need to adopt a ‘warrior mentality’, and remain positive and optimistic from diagnosis through treatment to stand a better chance of beating their cancer. To these patients, seeking help for the emotional issues they face is akin to admitting weakness,” said Dr. Chan. “There needs to be greater awareness that there is nothing wrong with getting help to manage the emotional upheaval — particularly depression, anxiety, and PTSD — post-cancer.”

    Dr. Chan also stressed that many patients live in fear that their cancer may come back, and they may think the cancer has returned with every lump or bump, pain or ache, fatigue or fever. In addition, survivors might skip visits to their oncologists or other physicians to avoid triggering memories of their past cancer experience. This can lead to delays in seeking help for new symptoms or even refusal of treatment for unrelated conditions.

    The researchers’ study also found that, compared with patients with other cancer types, patients with breast cancer were 3.7 times less likely to develop PTSD at six months, but not at four years. This may be because, at the referral center studied, there is a dedicated program that provides support and counselling, focusing mostly on breast cancer patients within the first year of cancer diagnosis.

    “We need psychological evaluation and support services for patients with cancer at an initial stage and at continued follows-up because psychological well-being and mental health — and by extension, quality of life — are just as important as physical health,” said Dr. Chan.


  2. Injury from contact sport has harmful, though temporary effect on memory

    November 22, 2017 by Ashley

    From the McMaster University press release:

    McMaster University neuroscientists studying sports-related head injuries have found that it takes less than a full concussion to cause memory loss, possibly because even mild trauma can interrupt the production of new neurons in a region of the brain responsible for memory.

    Though such losses are temporary, the findings raise questions about the long-term effects of repeated injuries and the academic performance of student athletes.

    The researchers spent months following dozens of athletes involved in high-contact sports such as rugby and football, and believe that concussions and repetitive impact can interrupt neurogenesis — or the creation of new neurons — in the hippocampus, a vulnerable region of the brain critical to memory.

    The findings were presented today (Tuesday, November 14th) at the Society for Neuroscience’s annual conference, Neuroscience 2017, in Washington D.C.

    “Not only are newborn neurons critical for memory, but they are also involved in mood and anxiety,” explains Melissa McCradden, a neuroscience postdoctoral fellow at McMaster University who conducted the work. “We believe these results may help explain why so many athletes experience difficulties with mood and anxiety in addition to memory problems.”

    For the study, researchers administered memory tests and assessed different types of athletes in two blocks over the course of two years. In the first block, they compared athletes who had suffered a concussion, uninjured athletes who played the same sport, same-sport athletes with musculoskeletal injuries, and healthy athletes who acted as a control group.

    Concussed athletes performed worse on the memory assessment called a mnemonic similarity test (MST), which evaluates a person’s ability to distinguish between images that are new, previously presented, or very similar to images previously presented.

    In the second study, rugby players were given the MST before the season started, halfway through the season, and one month after their last game. Scores for injured and uninjured athletes alike dropped midseason, compared to preseason scores, but recovered by the postseason assessment.

    Both concussed and non-concussed players showed a significant improvement in their performance on the test after a reprieve from their sport.

    For the concussed athletes, this occurred after being medically cleared to return to full practice and competition. For the rugby players, they improved after approximately a month away from the sport.

    If neurogenesis is negatively affected by concussion, researchers say, exercise could be an important tool in the recovery process, since it is known to promote the production of neurons. A growing body of new research suggests that gentle exercise which is introduced before a concussed patient is fully symptom free, is beneficial.

    “The important message here is that the brain does recover from injury after a period of reprieve,” says McCradden. “There is a tremendous potential for the brain to heal itself.”


  3. Researchers develop psychotherapy treatment for refugees’ trauma

    November 13, 2017 by Ashley

    From the Bielefeld University press release:

    They are suffering from nightmares, flashbacks, depression, or anxiety disorders: refugees coming to Germany from conflict areas are frequently traumatized. ‘Realistic estimates state that up to 40 per cent of refugees have mental problems. Hence, for the period since 2015, we are talking about several hundred thousand people who are in real need of psychological support,’ says Professor Dr. Frank Neuner from Bielefeld University. The psychologist is one of the team responsible for developing ‘Narrative Exposure Therapy’ (NET). It has been applied over the last 15 years in conflict zones from East Africa to Sri Lanka. What is special about this therapy is that it shows success after only a few sessions. In a new ‘research_tv’ programme at Bielefeld University, Frank Neuner talks about NET and explains the consequences of leaving refugees without treatment.

    ‘I believe that a large part of the general population is willing to accept that we now need to invest substantially in dealing with these traumatized refugees and that the state must make money available for this,’ says Frank Neuner. ‘Due to the threats in their home countries, many refugees will be staying with us for a long time. By helping them now, we shall be warding off problems that will otherwise confront us unavoidably in 20 or 30 years time.’

    Neuner designed and tested NET together with Dr. Maggie Schauer and Professor Dr. Thomas Elbert from the University of Konstanz. By working with this method, hundreds of child soldiers, victims of political violence, and war refugees have been able to process their traumatic experiences.

    The key principle of NET is a highly valued practice in every culture: telling stories. ‘Whenever we have gone through an emotional experience, we try to tell stories. This is how we try to make what we have experienced comprehensible to others,’ says Neuner. ‘Refugees have experienced a whole series of traumatic events. We talk together with them about their entire life history and build up a kind of autobiography that enables them to embed the single traumatic experiences in a meaningful context and work out the significance they have in their own personal lives.’ Together with their therapist, traumatized persons work their way repeatedly and chronologically through the negative and positive events in their lives. ‘The idea is to historicize the traumatic events. This permits closure, so that they no longer threaten the present.’

    To deliver therapy to people in crisis zones, Neuner together with colleagues from the University of Konstanz and further supporters founded the aid organisation ‘Vivo’. It is training lay therapists in countries such as Sri Lanka, Ruanda, Uganda, and the Congo. Unlike Germany, the health systems of these countries do not provide access to professional therapists. ‘However, even Germany does not have enough therapists to treat all the refugees with traumatic disorders. Many people in Germany already have to wait months for a treatment slot with a therapist,’ says Neuner. ‘One step towards a solution could be to give NET training to refugees and migrants here in Germany and to employ them within a stepped care model supervised by psychotherapists. However, the German legal situation does not permit this at present.’

    NET is already being practiced by professional therapists in Germany. Bielefeld University’s psychotherapy clinic is applying the method in therapy studies not only refugees with but also with survivors of child abuse, rape victims, and former members of the German military. The scientific further education centres at Bielefeld University and the University of Konstanz are qualifying psychologists, medical doctors, and psychotherapists to work with NET.


  4. Locus coeruleus activity linked with hyperarousal in PTSD

    November 9, 2017 by Ashley

    From the Elsevier press release:

    A new study in Biological Psychiatry has linked signs of heightened arousal and reactivity — a core symptom of posttraumatic stress disorder (PTSD) — to overactivity of the locus coeruleus (LC), a brain region that mediates arousal and reactivity. By combining bodily responses and brain imaging data, the new paper by Dr. Christoph Mueller-Pfeiffer at the University of Zurich, Switzerland and colleagues is the first to provide direct human evidence for a theory over 30 years old. Pinpointing the origin of symptoms in the brain is a major step in efforts to improve treatment options for patients with the disorder.

    “The authors are to be congratulated on imaging this part of the brain,” said Dr. John Krystal, Editor of Biological Psychiatry. “Demonstrating the presence of LC hyperactivity in PTSD sets the stage for clarifying the relationship of LC activity to stress response, resilience, PTSD symptoms, and the treatment of PTSD,” he added.

    In the study, first author Christoph Naegeli, also of University of Zurich, and colleagues analyzed 54 participants who had been exposed to trauma, about half of whom developed PTSD. When the participants listened to random bursts of white noise, those who were diagnosed with PTSD had more frequent eye blinks, and increased heart rate, skin conductance and pupil area responses — indicators of the body’s autonomic response — than participants without PTSD.

    Using functional magnetic resonance imaging to measure brain activity, Naegeli and colleagues found that patients with PTSD had larger brain responses in the LC and other regions wired to the LC that control alertness and motor preparation. According to Mueller-Pfeiffer, the increased brain activity and autonomic responses measured in the participants provide a biologically plausible explanation for hypervigilance and exaggerated startle responses in PTSD. However, LC activation was not directly associated with arousal symptoms. Thus, direct links between LC hyperactivity and PTSD symptom severity still need to be demonstrated.

    The study may also reveal new avenues for treating these common and disabling symptoms of PTSD. “Our results suggest that targeting locus coeruleus system hyperactivity with new pharmacological or psychotherapeutic interventions are approaches worthy of further investigation,” said Dr. Mueller-Pfeiffer.


  5. Study identifies mechanism that helps us inhibit unwanted thoughts

    November 5, 2017 by Ashley

    From the University of Cambridge press release:

    Scientists have identified a key chemical within the ‘memory’ region of the brain that allows us to suppress unwanted thoughts, helping explain why people who suffer from disorders such as anxiety, post-traumatic stress disorder (PTSD), depression, and schizophrenia often experience persistent intrusive thoughts when these circuits go awry.

    We are sometimes confronted with reminders of unwanted thoughts — thoughts about unpleasant memories, images or worries. When this happens, the thought may be retrieved, making us think about it again even though we prefer not to. While being reminded in this way may not be a problem when our thoughts are positive, if the topic was unpleasant or traumatic, our thoughts may be very negative, worrying or ruminating about what happened, taking us back to the event.

    “Our ability to control our thoughts is fundamental to our wellbeing,” explains Professor Michael Anderson from the Medical Research Council Cognition and Brain Sciences Unit at the University of Cambridge. “When this capacity breaks down, it causes some of the most debilitating symptoms of psychiatric diseases: intrusive memories, images, hallucinations, ruminations, and pathological and persistent worries. These are all key symptoms of mental illnesses such as PTSD, schizophrenia, depression, and anxiety.”

    Professor Anderson likens our ability to intervene and stop ourselves retrieving particular memories and thoughts to stopping a physical action. “We wouldn’t be able to survive without controlling our actions,” he says. “We have lots of quick reflexes that are often useful, but we sometimes need to control these actions and stop them from happening. There must be a similar mechanism for helping us stop unwanted thoughts from occurring.”

    A region at the front of the brain known as the prefrontal cortex is known to play a key role in controlling our actions and has more recently been shown to play a similarly important role in stopping our thoughts. The prefrontal cortex acts as a master regulator, controlling other brain regions — the motor cortex for actions and the hippocampus for memories.

    In research published today in the journal Nature Communications, a team of scientists led by Dr Taylor Schmitz and Professor Anderson used a task known as the ‘Think/No-Think’ procedure to identify a significant new brain process that enables the prefrontal cortex to successfully inhibit our thoughts.

    In the task, participants learn to associate a series of words with a paired, but otherwise unconnected, word, for example ordeal/roach and moss/north. In the next stage, participants are asked to recall the associated word if the cue is green or to suppress it if the cue is red; in other words, when shown ‘ordeal’ in red, they are asked to stare at the word but to stop themselves thinking about the associated thought ‘roach’.

    Using a combination of functional magnetic resonance imaging (fMRI) and magnetic resonance spectroscopy, the researchers were able to observe what was happening within key regions of the brain as the participants tried to inhibit their thoughts. Spectroscopy enabled the researchers to measure brain chemistry, and not just brain activity, as is usually done in imaging studies.

    Professor Anderson, Dr Schmitz and colleagues showed that the ability to inhibit unwanted thoughts relies on a neurotransmitter — a chemical within the brain that allows messages to pass between nerve cells — known as GABA. GABA is the main ‘inhibitory’ neurotransmitter in the brain, and its release by one nerve cell can suppress activity in other cells to which it is connected. Anderson and colleagues discovered that GABA concentrations within the hippocampus — a key area of the brain involved in memory — predict people’s ability to block the retrieval process and prevent thoughts and memories from returning.

    “What’s exciting about this is that now we’re getting very specific,” he explains. “Before, we could only say ‘this part of the brain acts on that part’, but now we can say which neurotransmitters are likely important — and as a result, infer the role of inhibitory neurons — in enabling us to stop unwanted thoughts.”

    “Where previous research has focused on the prefrontal cortex — the command centre — we’ve shown that this is an incomplete picture. Inhibiting unwanted thoughts is as much about the cells within the hippocampus — the ‘boots on the ground’ that receive commands from the prefrontal cortex. If an army’s foot-soldiers are poorly equipped, then its commanders’ orders cannot be implemented well.”

    The researchers found that even within his sample of healthy young adults, people with less hippocampal GABA (less effective ‘foot-soldiers’) were less able to suppress hippocampal activity by the prefrontal cortex — and as a result much worse at inhibiting unwanted thoughts.

    The discovery may answer one of the long-standing questions about schizophrenia. Research has shown that people affected by schizophrenia have ‘hyperactive’ hippocampi, which correlates with intrusive symptoms such as hallucinations. Post-mortem studies have revealed that the inhibitory neurons (which use GABA) in the hippocampi of these individuals are compromised, possibly making it harder for the prefrontal cortex to regulate activity in this structure. This suggests that the hippocampus is failing to inhibit errant thoughts and memories, which may be manifest as hallucinations.

    According to Dr Schmitz, “The environmental and genetic influences that give rise to hyperactivity in the hippocampus might underlie a range of disorders with intrusive thoughts as a common symptom.”

    In fact, studies have shown that elevated activity in the hippocampus is seen in a broad range of conditions such as PTSD, anxiety and chronic depression, all of which include a pathological inability to control thoughts — such as excessive worrying or rumination.

    While the study does not examine any immediate treatments, Professor Anderson believes it could offer a new approach to tackling intrusive thoughts in these disorders. “Most of the focus has been on improving functioning of the prefrontal cortex,” he says, “but our study suggests that if you could improve GABA activity within the hippocampus, this may help people to stop unwanted and intrusive thoughts.”

    The research was funded by the Medical Research Council.


  6. Study suggests that brain region for balance, movement also involved in processing traumatic memories

    October 29, 2017 by Ashley

    From the Thomas Jefferson University press release:

    Patients diagnosed and treated for a long-term potentially fatal diseases such as cancer, can accumulate distressing and traumatic experiences along the way. A new study from the Marcus Institute of Integrative Health at Thomas Jefferson University examines how the brain is activated when the Neuro Emotional Technique (NET) is used to help cancer patients process traumatic memories. The research, published in the Journal of Cancer Survivorship, also adds to the basic understanding of the pathophysiology of traumatic stress in general and the underlying mechanisms involved with resolving it.

    “The results of this study are a breakthrough in understanding how an intervention like NET works, particularly in regard to the cerebellum’s role in the regulation of emotional experiences. We now understand that the cerebellum does much more than coordinate motor activity,” said principal investigator Daniel Monti, MD, MBA, Director of the Marcus Institute of Integrative Health who is also a member of the Sidney Kimmel Cancer Center at Jefferson.

    The intervention, Neuro Emotional Technique (NET), is unique in allowing the practitioner to not only gauge the patient’s subjective distress but also how the nervous system is reacting to that stress, using biofeedback tools. This provides information that is not usually part of standard interventions, and is what potentially makes NET an especially efficient and efficacious therapeutic solution for traumatic stress. By showing the link between the cerebellum, limbic (emotional) centers, and autonomic nervous system, the present study expands current understanding of traumatic memories and how and intervention like NET can significantly alleviate the suffering associated with them.

    “This is the first study that offers a demonstrable solution for cancer patients with traumatic stress symptoms. It also expands our understanding of the importance of the cerebellum in coordinating traumatic emotions, and the body’s response to them,” said Dr. Monti.

    This new data suggests that a brief therapeutic course of the NET intervention substantially alters the brain’s response to traumatic memories, and it elucidates the potential importance of the cerebellum in regulating the brain and body’s response to traumatic stress. (Previous research from the Marcus Institute demonstrated the efficacy of the NET intervention for relieving stress in cancer patients.)

    “Just four to five brief NET sessions result in significantly less emotional and physical distress, and these improvements are associated with connectivity changes throughout the brain,” said Dr. Monti. “Patients, even those who were skeptical at first, have reported the NET intervention as ‘diffusing a bomb’ on ‘the worst anxiety ever.'”


  7. Mysterious DNA modification seen in stress response

    October 25, 2017 by Ashley

    From the Emory Health Sciences press release:

    With advances in genomics, scientists are discovering additional components of the DNA alphabet in animals. Do these unusual chemical modifications of DNA have a special meaning, or are they just signs that cellular machines are making mistakes?

    Geneticists at Emory University School of Medicine led by Peng Jin, PhD have been studying a modification of DNA that is not well understood in animals: methylation of the DNA letter A (adenine). They’ve found that it appears more in the brain under conditions of stress, and may have a role in neuropsychiatric disorders.

    The results are scheduled for publication in Nature Communications.

    Methylation on the DNA letter C (cytosine) generally shuts genes off and is an important part of epigenetic regulation, a way for cells to change how the DNA code is read without altering the DNA letters themselves. Methylation describes a mark consisting of an extra carbon atom and three hydrogens: -CH3.

    What if methylation appears on adenine? In bacteria, N6-methyladenine is part of how they defend themselves against invasion by phages (viruses that infect bacteria). The same modification was recently identified as present in the DNA of insects and mammals, but this epigenetic flourish has been awaiting a full explanation of its function.

    Just to start, having that extra -CH3 jutting out of the DNA could get in the way of proteins that bind DNA and direct gene activity. For C-methylation, scientists know a lot about the enzymes that grab it, add it or erase it. For A-methylation, less is known.

    “We found that 6-methyl A is dynamic, which could suggest a functional role,” Jin says. “That said, the enzymes that recognize, add and erase this type of DNA methylation are still mysterious.”

    It does appear that the enzymes that add methyl groups to A when it is part of RNA are not involved, he adds.

    First author Bing Yao, PhD, assistant professor of human genetics, recently established his own laboratory at Emory to examine these and other emerging parts of the DNA alphabet. Jin is vice chair of research in the Department of Human Genetics.

    In the Nature Communications paper, Yao, Jin and their colleagues looked at the prefrontal cortex region of the brain in mice that were subjected to stress, in standard models for the study of depression (forced swim test and tail suspension test).

    Under these conditions, the abundance of N6-methyladenine in the brain cells’ DNA rose four-fold, the scientists found. The DNA modification was detected with two sensitive techniques: liquid chromatography/mass spectrometry and binding to an antibody against N6-methyladenine. The peak abundance is about 25 parts per million, which isn’t that high — but it appears to be confined to certain regions of the genome.

    The methyl-A modification tended to appear more in regions that were between genes and was mostly excluded from the parts of the genome that encode proteins. The loss of methyl-A correlates with genes that are upregulated with stress, suggesting that something removes it around active genes. There does seem to be some “cross talk” between A and C methylation, Jin adds.

    Genes bearing stress-induced 6mA changes overlapped with those associated with neuropsychiatric disorders; a relationship that needs more investigation. The scientists speculate that aberrant 6mA in response to stress could contribute to neuropsychiatric diseases by ectopically recruiting DNA binding proteins.

    The research was supported in part by the National Institute of Neurological Disorders and Stroke (NS051630, NS097206) and the National Institute of Mental Health (MH102690).


  8. Study suggests predicting depression and PTSD before deployment could help soldiers cope

    October 17, 2017 by Ashley

    From the BioMed Central press release:

    A set of validated, self-reported questions administered early in a soldier’s career could predict mental health problems such as depression and post-traumatic stress disorder (PTSD) after return from deployment, according to a study published in the open access journal BMC Psychology.

    The questions assess 14 psychological attributes such as adaptability, coping ability and optimism. They could be used to identify high-risk individuals and provide them with psychological and social resources to help them cope with stressors of deployment including combat trauma and extended separation from friends and family, researchers at Naval Postgraduate School and Research Facilitation Laboratory, USA suggest.

    In addition to scoring psychological health attributes before deployment, the researchers also generated an individual, composite risk score for each soldier using baseline psychological attributes and demographic information such as gender, age, race/ethnicity, marital status, education, and military occupation group. They found that out of those whose score classified them as being at highest risk for psychological health disorders (i.e. at the top 5% of the score), 31% screened positive for depression, while 27% screened positive for PTSD after return from deployment.

    Professor Yu-Chu Shen, lead author of the study said: “We found that soldiers who had the worst pre-military psychological health attribute scores — those in the bottom 5% of scores — carried much higher odds of screening positive for depression and PTSD after returning home than the top 95%. Soldiers who score worst before deployment might be more susceptible to developing debilitating mental health disorders when they are later exposed to combat environments.”

    The findings suggest that psychological screening before deployment, in combination with other personnel information, can be helpful in identifying individuals who carry significant risk for psychological health disorders, according to the authors. Being aware of this risk could enable tailored interventions to increase soldiers’ psychological health prior to exposing them to combat. Identifying individuals at risk of adverse psychological outcomes could also translate into savings on costs resulting from treatment and lost productivity.

    To investigate the association of psychological attributes in soldiers before deployment and their risk for depression and PTSD after their return, the authors used data from three sources on 63,138 soldiers who enlisted after 2008: the Army’s personnel database, pre- and post-deployment health assessments, and the Global Assessment Tool (GAT).

    GAT is an annual resilience and psychological health assessment completed by all members of the US Army. It consists of a 105-item questionnaire that captures 14 attributes of health and resilience that are considered important for life in the military. These attributes include optimism and catastrophizing, which may reflect how a person responds to the stress of combat; positive affect and organisational trust, which capture how a person may respond to leadership; and resilience and coping ability.

    The authors caution that GAT in its current form is not designed to be used as a screening tool on which employment decisions should be based.

    Professor Shen said: “In this study, we illustrate the potential value for psychological health screening such as GAT in public safety and national defense occupations. However, for any strategy based on screenings like this to be successful and effective, we also highlight the importance for future screening tools to be designed to detect and minimize strategic responding — that is personnel adapting their answers if they know that their career progression and chance of deployment may depend on their screening scores. Strategic responding may undermine the effectiveness of a screening tool in identifying the risk for mental health disorders.”


  9. Study looks at psychological impacts of natural disasters on youth

    October 4, 2017 by Ashley

    From the University of Miami press release:

    Children’s mental state plays an important factor in their developmental growth. After recent storms devastated parts of the U.S. — Hurricane Harvey in Texas, Hurricane Irma in Florida and the Caribbean and Hurricane Maria in Puerto Rico — all contributing to massive evacuations of children and families, which children need more attention or support services in the aftermath of these storms and the related stressors that come with surviving and witnessing the destructive power of a Category 4 or 5 hurricane?

    Distinguished Professor of Psychology and Pediatrics at the University of Miami, Annette M. La Greca, is fully aware of children’s reaction to trauma. Her research focuses on the impact of disasters on youth since Hurricane Andrew struck South Florida in 1992.

    La Greca, in collaboration with her UM graduate student, BreAnne Danzi, has been evaluating how best to define post-traumatic stress disorder (PTSD) in children. This line of research will help to quickly identify the children who need support services post-disaster. La Greca’s research has also identified key aspects of the post-disaster environment that facilitate children’s recovery.

    “The good news is that most children are resilient, even after a very devastating storm,” said La Greca. However, children have different ways of expressing distress than adults.

    In a paper entitled, “Optimizing clinical thresholds for PTSD: Extending the DSM-5 preschool criteria to school-age children,” recently published in the International Journal of Clinical and Health Psychology, La Greca and Danzi examined how well the “preschool” definition of PTSD identifies school-aged children with significant distress after a major hurricane.

    According to the study, 327 children (ages 7-11) from six elementary schools in Galveston, Texas, which were directly in the path of Hurricane Ike, a Category 2 storm that made landfall in September 2008, participated. They found that the preschool definition of PTSD identifies more distressed children than the typical “adult-based” definition. Thus, the preschool definition may be useful when screening elementary school-age children (ages 7-11) for PTSD-risk.

    Additional research by La Greca and colleagues also found that two-thirds of children who are initially distressed after a disaster recover naturally over the course of the school year. Children who recover report having more social support from friends and family, fewer life stressors in the disaster’s aftermath and more positive coping skills than those who remain chronically distressed.

    “We now know from research that some children who endured a stressful evacuation or experienced scary or life-threatening events during the storm are at risk for a poor recovery over time,” she said. “Children who need extra support include those who report feeling anxious or depressed, as well as stressed, and who lack social support from friends and family. They also have multiple stressors to deal with after the storm. All of those factors contribute to poor recovery and less resilience.”

    Based on these findings, La Greca and colleagues developed a workbook, After the Storm, for parents to help their children cope after a hurricane (available for a free download at http://www.7-dippity.com/other/op_storm.html

    ). The guide has been widely used after Hurricanes Katrina, Rita and Ike.The workbook addresses ways to help most children recover, such as having a normal routine, staying connected to friends and family, eating healthy, exercising, resuming leisure activities, proper sleep and avoiding media or online coverage of aftermath damage and distress. La Greca added that helping others in need and identifying things to be grateful for can also help to maintain a positive perspective.

    “There is no doubt that hurricanes and other extreme weather events can be stressful for children and for adults,” said La Greca. “But as with many stressful experiences, a little extra support can go a long way.”


  10. Study explains why stress hormone can prevent disorders after exposure to traumatic event

    September 25, 2017 by Ashley

    From the Universitat Autònoma de Barcelona press release:

    People who have suffered from traffic accidents, war combat, terrorist attacks and exposure to other traumatic events have an increased likelihood of developing diseases. These diseases can be psychological and physical, such as heart problems and cancer. The current preventive treatments based on psychological support and drugs are effective in some cases. Unfortunately, these treatments do not work for many individuals. It is also known that the earlier the treatment starts the better to prevent future negative consequences.

    Researchers at the Institut de Neurociències of the Universitat Autònoma de Barcelona (INc-UAB, Spain) have discovered in a study with mice and humans that the Ppm1f (Protein phosphatase 1f) gene expression is one of the most highly regulated after exposure to traumatic stress. Moreover, Ppm1f is associated with posttraumatic stress disorder (PTSD), depression and anxiety. The main function of Ppm1f is to regulate the activity of the protein Camk2 (Calmodulin-dependent protein kinase 2), which is key in many processes of the human body such as memory, the heart’s functioning and the immune system.

    According to Dr. Raül Andero Galí, lead researcher in this study, “Once we discovered the relationship between the Ppm1f gene and different psychological disorders after exposure to traumatic stress, we wanted to find an effective drug to prevent these changes and its negative consequences on the brain.” Dr Andero is scientist at the INc-UAB. It was already known that dosing the stress hormone — a glucocorticoid — few hours after exposure to a traumatic event may decrease the likelihood of developing psychological disorders. Thus, the scientists administered the hormone to mice one hour after exposure to stress. “The results confirmed a decrease in the symptoms of anxiety and depression, and also that this effect is because the Ppm1f gene changes are prevented,” explains Dr. Eric Velasco, researcher at the INc-UAB and co-author of the study.

    “The apparent contradiction that the stress hormone decreases the likelihood of developing diseases after exposure to traumatic stress is one of the greatest paradoxes of current medicine” Andero says. “This study sheds light on this paradox and uncovers a way by which the stress hormone could prevent diseases, at least psychologically, through regulation of the Ppm1f gene” he adds.

    Until now, the stress hormone has been administered to people in very few cases. “Our discovery opens the door to a broader application and to the development of treatments aimed specifically at regulating this gene’s functions,” says Antonio Florido, researcher of the INc-UAB and also co-author of the paper.

    The study was carried out in collaboration with the universities of Harvard and Emory (United States). This work is published in Biological Psychiatry, one of the most important journals in Neuroscience. The UAB researchers are currently interested in collaborating with other laboratories and obtaining funding to continue the studies of Ppm1f associated with other disorders such as cardiovascular diseases and cancer in order to verify whether their results are comparable in other diseases and potentially prevent them.