Kimchi and her research team, Aharon Weissbrod, Genady Wasserman and Alex Shapiro, together with Dr. Ofer Feinerman of the Institute\u2019s Physics of Complex Systems Department, developed a system that enabled them to observe a large group of animals living together in semi-natural conditions. This setup was a sort of mouse version of the television show Big Brother<\/em>. Different strains of mice were placed in the \u201chouse\u201d \u2013 a four-meter-square pen \u2013 and allowed to go about their lives with no intervention from the human team<\/strong>.<\/p>\n To automatically track the mice day and night, each mouse was implanted with an ID chip similar to those used in pet cats and dogs, and video cameras were placed strategically around the area with infrared lighting that enabled nighttime filming. With the combined chip reporting and continuous video footage, the system could automatically keep tabs on each individual mouse<\/strong>, knowing its precise location down to the half centimeter, in measurements that were recorded thirty times a second for days and sometimes even months on end.<\/p>\n Because the information they obtained was so precise, the team was able to identify dozens of individual behaviors \u2013 eating, drinking, running, sleeping, hiding, etc. \u2013 as well as social behaviors \u2013 seeking out specific companions for activities or rest, avoiding certain individuals, attacking others, and more. The researchers found that it was possible to isolate and identify typical behaviors of individuals, pairs and groups<\/strong>. In fact just by sorting out behavioral patterns, the automated system was able to differentiate between the various genetic strains of the mice in the mixed groups, as well as predicting mating, with over 90% accuracy. These close observations revealed, among other social features, how one of the individuals became \u201cking\u201d of the group, attaining dominance over the others, both male and female.<\/p>\n In further experiments, the \u201chouse\u201d inhabitants comprised one of two strains of mice, the first more \u201csocial\u201d and the second \u201cautistic\u201d (exhibiting little social engagement and rigid behavior patterns). The system automatically identified the \u201cautistic\u201d mice by identifying their patterns of movement and public behavior<\/strong>.<\/p>\n In a paper that appears this week in Nature Communications<\/em>, Kimchi and her team describe the emergence of the dominant leader and the development of a class system in a group of normal mice \u2013 just within a 24-hour period. Surprisingly, when they conducted a similar experiment with the autistic-like mice, either no leader emerged or, if one did, he was quickly overthrown.<\/p>\n The precise, automatic, semi-natural system the scientists have developed is enabling a deep, systematic study of the mechanisms for regulating social behavior in animal models<\/strong>; it may be especially useful for providing insight into the societal aspects of such disorders as schizophrenia and autism.<\/p><\/blockquote>\n","protected":false},"excerpt":{"rendered":" From the Weizmann Institute press release via EurekAlert!: How does a social animal \u2013 mouse or human \u2013 gain dominance over his or her fellow creatures? A unique experiment conducted… Read more »<\/a><\/p>\n","protected":false},"author":5,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":[],"categories":[331],"tags":[71,72,13,98],"_links":{"self":[{"href":"https:\/\/therapytoronto.ca\/news\/wp-json\/wp\/v2\/posts\/14110"}],"collection":[{"href":"https:\/\/therapytoronto.ca\/news\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/therapytoronto.ca\/news\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/therapytoronto.ca\/news\/wp-json\/wp\/v2\/users\/5"}],"replies":[{"embeddable":true,"href":"https:\/\/therapytoronto.ca\/news\/wp-json\/wp\/v2\/comments?post=14110"}],"version-history":[{"count":4,"href":"https:\/\/therapytoronto.ca\/news\/wp-json\/wp\/v2\/posts\/14110\/revisions"}],"predecessor-version":[{"id":14228,"href":"https:\/\/therapytoronto.ca\/news\/wp-json\/wp\/v2\/posts\/14110\/revisions\/14228"}],"wp:attachment":[{"href":"https:\/\/therapytoronto.ca\/news\/wp-json\/wp\/v2\/media?parent=14110"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/therapytoronto.ca\/news\/wp-json\/wp\/v2\/categories?post=14110"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/therapytoronto.ca\/news\/wp-json\/wp\/v2\/tags?post=14110"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}![\"lab_mouse\"](\"http:\/\/therapytoronto.ca\/news\/wp-content\/uploads\/2012\/12\/lab_mouse.jpg\")
How does a social animal \u2013 mouse or human \u2013 gain dominance over his or her fellow creatures?<\/strong> A unique experiment conducted by Dr. Tali Kimchi and her team in the Weizmann Institute\u2019s Neurobiology Department provides some unusual insight into the social behavior that enables a social hierarchy, complete with a head honcho, to form.<\/p>\n