In a study led by scientists from Arizona State University, the University of Cambridge, University of Tartu and Estonian Biocentre, and published March 13 in an online issue of the journal\u00a0Genome Research<\/em>, researchers discovered a dramatic decline in genetic diversity in male lineages four to eight thousand years ago — likely the result of the accumulation of material wealth<\/strong>, while in contrast, female genetic diversity was on the rise. This male-specific decline occurred during the mid- to late-Neolithic period.<\/p>\n Melissa Wilson Sayres, a leading author and assistant professor with ASU’s School of Life Sciences, said, “Instead of ‘survival of the fittest’ in biological sense, the accumulation of wealth and power may have increased the reproductive success of a limited number of ‘socially fit’ males and their sons<\/strong>.”<\/p>\n It is widely recognized among scientists that a major bottleneck, or decrease in genetic diversity, occurred approximately 50 thousand years ago when a subset of humans left Africa and migrated across the rest of the world. Signatures of this bottleneck appear in most genes of non-African populations, whether they are inherited from both parents or, as confirmed in this study, only along the father’s or mother’s genetic lines.<\/p>\n “Most surprisingly to us, we detected another, male-specific, bottleneck during a period of global growth<\/strong>. The signal for this bottleneck dates to a time period four to eight thousand years ago, when humans in different parts of the world had become sedentary farmers,” said senior author Toomas Kivisild from the Division of Biological Anthropology, University of Cambridge.<\/p>\n Researchers studied DNA samples taken from the saliva or blood of 456 males living in seven regions of five continents including Africa, the Andes, South-Asia, near East and Central Asia, Europe and Oceania. Scientists specifically studied the Y chromosome, which is passed down through the male lineage, and the mitochondria, which is passed to offspring by the genetic mother.<\/p>\n After using computer and statistical modeling, they found the two extreme “bottlenecks” in human genetic history, specifically the second found only in the male lineage<\/strong>.<\/p>\n The researchers said studying genetic history is important for understanding underlying levels of genetic variation. Having a high level of genetic diversity is beneficial to humans for several reasons<\/strong>. First, when the genes of individuals in a population vary greatly, the group has a greater chance of thriving and surviving — particularly against disease. It may also reduce the likelihood of passing along unfavorable genetic traits, which can weaken a species over time.<\/p>\n According to Monika Karmin, a leading author from University of Tartu, Estonia, their findings may have implications related to human health.<\/p>\n “We know that some populations are predisposed to certain types of genetic disorders,” said Karmin. “Global population evolution is important to consider, especially as it relates to medicine.”<\/p>\n “When a doctor tries to provide a diagnosis when you are sick, you’ll be asked about your environment, what’s going on in your life, and your genetic history based on your family’s health,” added Wilson Sayres, who is also with ASU’s Biodesign Institute. “If we want to understand human health on a global scale, we need to know our global genetic history; that is what we are studying here<\/strong>.”<\/p>\n The researchers believe this will be relevant for informing patterns of genetic diversity across whole human populations, as well as informing their susceptibility to diseases.<\/p>\n Wilson Sayres said the next step is to continue the research by gathering a greater number of DNA samples, increasing the diversity of the samples<\/strong>, and working with anthropologists and sociologists to gain a broader perspective on the findings.<\/p><\/blockquote>\n The research was funded jointly by several sources, with primary support from the University of Tartu and Estonian Biocentre. Researchers from 66 institutions around the world participated in this study.<\/p>\n","protected":false},"excerpt":{"rendered":" From the Arizona State media release: The DNA you inherit from your parents contributes to the physical make-up of your body — whether you have blue eyes or brown, black… Read more »<\/a><\/p>\n","protected":false},"author":5,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":[],"categories":[344],"tags":[],"_links":{"self":[{"href":"https:\/\/therapytoronto.ca\/news\/wp-json\/wp\/v2\/posts\/17600"}],"collection":[{"href":"https:\/\/therapytoronto.ca\/news\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/therapytoronto.ca\/news\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/therapytoronto.ca\/news\/wp-json\/wp\/v2\/users\/5"}],"replies":[{"embeddable":true,"href":"https:\/\/therapytoronto.ca\/news\/wp-json\/wp\/v2\/comments?post=17600"}],"version-history":[{"count":2,"href":"https:\/\/therapytoronto.ca\/news\/wp-json\/wp\/v2\/posts\/17600\/revisions"}],"predecessor-version":[{"id":17602,"href":"https:\/\/therapytoronto.ca\/news\/wp-json\/wp\/v2\/posts\/17600\/revisions\/17602"}],"wp:attachment":[{"href":"https:\/\/therapytoronto.ca\/news\/wp-json\/wp\/v2\/media?parent=17600"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/therapytoronto.ca\/news\/wp-json\/wp\/v2\/categories?post=17600"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/therapytoronto.ca\/news\/wp-json\/wp\/v2\/tags?post=17600"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}![\"mouth](\"http:\/\/therapytoronto.ca\/news\/wp-content\/uploads\/2013\/01\/mouth_swab_dna_cortisol.jpg\")
<\/a>The DNA you inherit from your parents contributes to the physical make-up of your body — whether you have blue eyes or brown, black hair or red, or are male or female<\/strong>. Your DNA can also influence whether you might develop certain diseases or disorders such as Crohn’s Disease, cystic fibrosis, hemophilia or neurofibromatosis, to name a few.<\/p>\n