{"id":31397,"date":"2020-04-25T16:23:55","date_gmt":"2020-04-25T20:23:55","guid":{"rendered":"https:\/\/therapytoronto.ca\/news\/?p=31397"},"modified":"2020-04-14T03:16:15","modified_gmt":"2020-04-14T07:16:15","slug":"study-looks-at-how-stress-remodels-the-brain","status":"publish","type":"post","link":"https:\/\/therapytoronto.ca\/news\/2020\/04\/study-looks-at-how-stress-remodels-the-brain\/","title":{"rendered":"Study looks at how stress remodels the brain"},"content":{"rendered":"<p>From the Society for Neuroscience press release:<\/p>\n<blockquote><p><strong>Stress restructures the brain by halting the production of crucial ion channel proteins<\/strong>, according to research in mice recently published in\u00a0<strong><em>JNeurosci<\/em><\/strong>.<\/p>\n<p>Stress harms the brain and body in profound ways. One way is by <strong>altering astrocytes<\/strong>, the brain&#8217;s housekeepers tasked with mopping up neurotransmitters after they&#8217;ve been released into the synapse. On the cellular level, stress causes the branches of astrocytes to retract from the synapses they wrap around.<\/p>\n<p>Bender et al. investigated what controlled astrocyte changes after mice experienced exposure to the urine of a fox, their natural predator. This single stressful event caused quick but long-lasting retraction of the astrocyte&#8217;s branches. Stress induces this change by halting the production of GluA1, an essential subunit of glutamate receptors. During a stressful event, the stress hormone norepinephrine suppresses a molecular pathway that normally culminates in the protein synthesis of GluA1. Without functional GluA1 or glutamate receptors, <strong>neurons and astrocytes lose their ability to communicate with each other<\/strong>.<\/p><\/blockquote>\n<!-- AddThis Advanced Settings generic via filter on the_content --><!-- AddThis Share Buttons generic via filter on the_content -->","protected":false},"excerpt":{"rendered":"<p>From the Society for Neuroscience press release: Stress restructures the brain by halting the production of crucial ion channel proteins, according to research in mice recently published in\u00a0JNeurosci. Stress harms&#8230; <a class=\"read-more-link\" href=\"https:\/\/therapytoronto.ca\/news\/2020\/04\/study-looks-at-how-stress-remodels-the-brain\/\">Read more &raquo;<\/a><!-- AddThis Advanced Settings generic via filter on get_the_excerpt --><!-- AddThis Share Buttons generic via filter on get_the_excerpt --><\/p>\n","protected":false},"author":5,"featured_media":19859,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":[],"categories":[6,338],"tags":[42,457,93,62],"_links":{"self":[{"href":"https:\/\/therapytoronto.ca\/news\/wp-json\/wp\/v2\/posts\/31397"}],"collection":[{"href":"https:\/\/therapytoronto.ca\/news\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/therapytoronto.ca\/news\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/therapytoronto.ca\/news\/wp-json\/wp\/v2\/users\/5"}],"replies":[{"embeddable":true,"href":"https:\/\/therapytoronto.ca\/news\/wp-json\/wp\/v2\/comments?post=31397"}],"version-history":[{"count":2,"href":"https:\/\/therapytoronto.ca\/news\/wp-json\/wp\/v2\/posts\/31397\/revisions"}],"predecessor-version":[{"id":31451,"href":"https:\/\/therapytoronto.ca\/news\/wp-json\/wp\/v2\/posts\/31397\/revisions\/31451"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/therapytoronto.ca\/news\/wp-json\/wp\/v2\/media\/19859"}],"wp:attachment":[{"href":"https:\/\/therapytoronto.ca\/news\/wp-json\/wp\/v2\/media?parent=31397"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/therapytoronto.ca\/news\/wp-json\/wp\/v2\/categories?post=31397"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/therapytoronto.ca\/news\/wp-json\/wp\/v2\/tags?post=31397"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}