{"id":32821,"date":"2020-12-03T16:31:59","date_gmt":"2020-12-03T21:31:59","guid":{"rendered":"https:\/\/therapytoronto.ca\/news\/?p=32821"},"modified":"2020-12-08T03:33:37","modified_gmt":"2020-12-08T08:33:37","slug":"mouse-study-suggests-sleep-deprivation-may-affect-susceptibility-to-cocaine-addiction","status":"publish","type":"post","link":"https:\/\/therapytoronto.ca\/news\/2020\/12\/mouse-study-suggests-sleep-deprivation-may-affect-susceptibility-to-cocaine-addiction\/","title":{"rendered":"Mouse study suggests sleep deprivation may affect susceptibility to cocaine addiction"},"content":{"rendered":"<p>From the Society for Neuroscience press release:<\/p>\n<blockquote>\n<p id=\"first\" class=\"lead\"><strong>Sleep deprivation may pave the way to cocaine addiction<\/strong>. Too-little sleep can increase the rewarding properties of cocaine, according to new research in mice published in\u00a0<strong><em>eNeuro<\/em><\/strong>.<\/p>\n<div id=\"text\">\n<p>Poor sleep and cocaine use go hand-in-hand. Both acute and chronic cocaine use disrupts sleep, and sleep disturbances can increase the likelihood of relapse. But it&#8217;s unclear how <strong>sleep deprivation contributes to cocaine addiction<\/strong>. The orexin system, which influences motivated and addictive behaviors through the peptide orexin, may underlie the relationship: orexin activity increases during sleep deprivation, and blocking orexin receptors reduces reward-seeking.<\/p>\n<p>Bjorness and Greene conditioned mice to associate a room with cocaine and examined how sleep deprivation affected their ability to develop a preference for the cocaine room. <strong>Sleep-deprived mice formed a preference for a lower dose of cocaine, one that did not affect rested mice<\/strong>. They also formed a stronger preference for a standard cocaine dose, indicating an increase in the amount of reward cocaine provided. Blocking the orexin system reduced the increased cocaine preference driven by sleep deprivation.<\/p>\n<\/div>\n<div class=\"impact-unit-wrapper\">\n<div class=\"pgs-dpg-btn\" data-pgs-partner-id=\"sciencedaily\" data-loaded=\"true\"><\/div>\n<\/div>\n<\/blockquote>\n<!-- AddThis Advanced Settings generic via filter on the_content --><!-- AddThis Share Buttons generic via filter on the_content -->","protected":false},"excerpt":{"rendered":"<p>From the Society for Neuroscience press release: Sleep deprivation may pave the way to cocaine addiction. Too-little sleep can increase the rewarding properties of cocaine, according to new research in&#8230; <a class=\"read-more-link\" href=\"https:\/\/therapytoronto.ca\/news\/2020\/12\/mouse-study-suggests-sleep-deprivation-may-affect-susceptibility-to-cocaine-addiction\/\">Read more &raquo;<\/a><!-- AddThis Advanced Settings generic via filter on get_the_excerpt --><!-- AddThis Share Buttons generic via filter on get_the_excerpt --><\/p>\n","protected":false},"author":5,"featured_media":20273,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":[],"categories":[350,43],"tags":[21,362],"_links":{"self":[{"href":"https:\/\/therapytoronto.ca\/news\/wp-json\/wp\/v2\/posts\/32821"}],"collection":[{"href":"https:\/\/therapytoronto.ca\/news\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/therapytoronto.ca\/news\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/therapytoronto.ca\/news\/wp-json\/wp\/v2\/users\/5"}],"replies":[{"embeddable":true,"href":"https:\/\/therapytoronto.ca\/news\/wp-json\/wp\/v2\/comments?post=32821"}],"version-history":[{"count":2,"href":"https:\/\/therapytoronto.ca\/news\/wp-json\/wp\/v2\/posts\/32821\/revisions"}],"predecessor-version":[{"id":32891,"href":"https:\/\/therapytoronto.ca\/news\/wp-json\/wp\/v2\/posts\/32821\/revisions\/32891"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/therapytoronto.ca\/news\/wp-json\/wp\/v2\/media\/20273"}],"wp:attachment":[{"href":"https:\/\/therapytoronto.ca\/news\/wp-json\/wp\/v2\/media?parent=32821"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/therapytoronto.ca\/news\/wp-json\/wp\/v2\/categories?post=32821"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/therapytoronto.ca\/news\/wp-json\/wp\/v2\/tags?post=32821"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}