{"id":3510,"date":"2012-06-08T15:43:25","date_gmt":"2012-06-08T19:43:25","guid":{"rendered":"http:\/\/therapytoronto.ca\/news\/?p=3510"},"modified":"2012-06-09T14:48:42","modified_gmt":"2012-06-09T18:48:42","slug":"study-finds-fish-show-autism-like-gene-expression-in-water-with-psychoactive-pharmaceuticals","status":"publish","type":"post","link":"https:\/\/therapytoronto.ca\/news\/2012\/06\/study-finds-fish-show-autism-like-gene-expression-in-water-with-psychoactive-pharmaceuticals\/","title":{"rendered":"Study finds fish show autism-like gene expression in water with psychoactive pharmaceuticals"},"content":{"rendered":"<p>From the <em>PLoS<\/em> press release via ScienceDaily:<\/p>\n<blockquote><p><strong><img loading=\"lazy\" class=\"alignright\" title=\"meds\" src=\"http:\/\/therapytoronto.ca\/images\/blogpics\/Meds.jpg\" alt=\"\" width=\"288\" height=\"200\" \/>Psychoactive medications in water affect the gene expression profiles of fathead minnows in a way that mimics the gene expression patterns associated with autism spectrum disorder in genetically susceptible humans<\/strong>, according to research published June 6 in the open access journal <em>PLoS ONE<\/em>. These results suggest a <strong>potential environmental trigger for autism spectrum disorder<\/strong> in this vulnerable population, the authors write.<\/p>\n<p>The researchers, led by Michael A. Thomas of Idaho State University, exposed the fish to three psychoactive pharmaceuticals &#8212; fluoxetine, a selective serotonin reuptake inhibitor, or SSR1; venlafaxine, a serotonin-norepinephrine reuptake inhibitor, and carbamazepine, used to control seizures &#8212; at concentrations comparable to the highest estimated environmental levels.<\/p>\n<p>They found that the only gene expression patterns affected were those associated with idiopathic autism spectrum disorders, caused by genetic susceptibility interacting with unknown environmental triggers. These results suggest that <strong>exposure to environmental psychoactive pharmaceuticals may play a role in the development of autism spectrum disorder in genetically predisposed individuals<\/strong>.<\/p>\n<p>Lead researcher Michael A. Thomas remarks, &#8220;While others have envisioned a causal role for psychotropic drugs in idiopathic autism, we were astonished to find evidence that this might occur at very low dosages, such as those found in aquatic systems.&#8221;<\/p><\/blockquote>\n<!-- AddThis Advanced Settings generic via filter on the_content --><!-- AddThis Share Buttons generic via filter on the_content -->","protected":false},"excerpt":{"rendered":"<p>From the PLoS press release via ScienceDaily: Psychoactive medications in water affect the gene expression profiles of fathead minnows in a way that mimics the gene expression patterns associated with&#8230; <a class=\"read-more-link\" href=\"https:\/\/therapytoronto.ca\/news\/2012\/06\/study-finds-fish-show-autism-like-gene-expression-in-water-with-psychoactive-pharmaceuticals\/\">Read more &raquo;<\/a><!-- AddThis Advanced Settings generic via filter on get_the_excerpt --><!-- AddThis Share Buttons generic via filter on get_the_excerpt --><\/p>\n","protected":false},"author":4,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":[],"categories":[10],"tags":[71,72,253,234],"_links":{"self":[{"href":"https:\/\/therapytoronto.ca\/news\/wp-json\/wp\/v2\/posts\/3510"}],"collection":[{"href":"https:\/\/therapytoronto.ca\/news\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/therapytoronto.ca\/news\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/therapytoronto.ca\/news\/wp-json\/wp\/v2\/users\/4"}],"replies":[{"embeddable":true,"href":"https:\/\/therapytoronto.ca\/news\/wp-json\/wp\/v2\/comments?post=3510"}],"version-history":[{"count":2,"href":"https:\/\/therapytoronto.ca\/news\/wp-json\/wp\/v2\/posts\/3510\/revisions"}],"predecessor-version":[{"id":3526,"href":"https:\/\/therapytoronto.ca\/news\/wp-json\/wp\/v2\/posts\/3510\/revisions\/3526"}],"wp:attachment":[{"href":"https:\/\/therapytoronto.ca\/news\/wp-json\/wp\/v2\/media?parent=3510"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/therapytoronto.ca\/news\/wp-json\/wp\/v2\/categories?post=3510"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/therapytoronto.ca\/news\/wp-json\/wp\/v2\/tags?post=3510"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}