Antibodies are the defense molecules of the body\u2019s immune system against foreign invaders. If the antibodies cease to distinguish between \u201cforeign\u201d and \u201cself\u201d, they attack the cells of the own body, and are thus referred to as autoantibodies. These can trigger autoimmune diseases. Using MR angiography and other methods, Marion Bimmler and her colleagues have now shown that the autoantibodies bind to specific surface proteins (alpha1 andrenergic receptors) of vascular cells and thereby damage the blood vessels of the brain<\/strong>. The reason: The autoantibodies generate a continual stimulation of the receptor and at the same time trigger an increase in intracellular calcium ion levels. As a result, the blood vessel walls thicken, and blood flow to the brain is disturbed.<\/p>\n First encouraging results after removal of autoantibodies by immunoadsorption<\/strong><\/p>\n In earlier studies, Marion Bimmler and her research team examined blood samples of patients with Alzheimer\u2018s or vascular dementia and showed that half of them had comparable autoantibodies<\/strong>. A first clinical trial together with Charit\u00e9 \u2013 Universit\u00e4tsmedizin Berlin is currently ongoing with a collective of patients with Alzheimer\u2019s or vascular dementia. The patients were divided into two groups \u2013 a small group whose autoantibodies were removed from the blood via immunoadsorption and a control group that did not receive this treatment. Until now, over an observation period of 6 and subsequently 12 months, the patient group who had undergone immunoadsorption improved in their memory performance and in their ability to cope with their everyday lives<\/strong>. In contrast, the condition of the patients who did not receive immunoadsorption treatment and continued to have autoantibodies in their blood deteriorated dramatically. Now the researchers are planning further clinical trials with larger numbers of patients.<\/p><\/blockquote>\n","protected":false},"excerpt":{"rendered":" From the Max Delbr\u00fcck Center for Molecular Medicine via ScienceDaily: The presence of specific autoantibodies of the immune system is associated with blood vessel damage in the brain. These findings… Read more »<\/a><\/p>\n","protected":false},"author":4,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":[],"categories":[10,4,6],"tags":[195,42,18,194],"_links":{"self":[{"href":"https:\/\/therapytoronto.ca\/news\/wp-json\/wp\/v2\/posts\/5242"}],"collection":[{"href":"https:\/\/therapytoronto.ca\/news\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/therapytoronto.ca\/news\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/therapytoronto.ca\/news\/wp-json\/wp\/v2\/users\/4"}],"replies":[{"embeddable":true,"href":"https:\/\/therapytoronto.ca\/news\/wp-json\/wp\/v2\/comments?post=5242"}],"version-history":[{"count":2,"href":"https:\/\/therapytoronto.ca\/news\/wp-json\/wp\/v2\/posts\/5242\/revisions"}],"predecessor-version":[{"id":5263,"href":"https:\/\/therapytoronto.ca\/news\/wp-json\/wp\/v2\/posts\/5242\/revisions\/5263"}],"wp:attachment":[{"href":"https:\/\/therapytoronto.ca\/news\/wp-json\/wp\/v2\/media?parent=5242"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/therapytoronto.ca\/news\/wp-json\/wp\/v2\/categories?post=5242"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/therapytoronto.ca\/news\/wp-json\/wp\/v2\/tags?post=5242"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}![\"\"](\"http:\/\/therapytoronto.ca\/images\/blogpics\/Brain4.jpg\" "\\"brain\\"")
The presence of specific autoantibodies of the immune system is associated with blood vessel damage in the brain<\/strong>. These findings were made by Marion Bimmler, a graduate engineer of medical laboratory diagnostics at the Max Delbr\u00fcck Center for Molecular Medicine (MDC) Berlin-Buch and Dr. Peter Karczewski of the biotech company E.R.D.E.-AAK-Diagnostik GmbH in studies on a rat model. The researchers\u2019 results suggest that autoimmune mechanisms play a significant role in the pathogenesis and progression of Alzheimer\u2019s and vascular dementia<\/strong> (PloS ONE<\/em>, doi:10.1371\/journal.pone.0041602)*.<\/p>\n