Wenhui Hu and colleagues point out that existing drugs for AD provide only \u201cminimal\u201d relief of memory loss and other symptoms<\/strong>, creating an urgent need for new medicines that actually combat the underlying destruction of brain cells. Research suggests that inflammation of nerve cells in the brain is a key part of that process. One medicine, Minozac, is in clinical trials. But Hu says Minozac still has more space to improve its efficacy. So the scientists sifted through compounds with a molecular architecture similar to Minozac in an effort to find more active substances.<\/p>\n The report describes success in doing so. They discovered one compound that appeared especially effective in relieving nerve inflammation and in improving learning and memory in lab mice widely used in AD research. \u201cIn general, this study not only proves that countering neuroinflammation is indeed a potential therapeutic strategy for Alzheimer\u2019s disease<\/strong>, but also provides a good lead compound with efficacy comparable to donepezil [an existing AD medicine] for further oral anti-AD drug discovery and development,\u201d the report states.<\/p><\/blockquote>\n","protected":false},"excerpt":{"rendered":" From the American Chemical Society press release via ScienceDaily: New research proves the validity of one of the most promising approaches for combating Alzheimer\u2019s disease (AD) with medicines that treat… Read more »<\/a><\/p>\n","protected":false},"author":4,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":[],"categories":[10,319,4,6],"tags":[195,42,194],"_links":{"self":[{"href":"https:\/\/therapytoronto.ca\/news\/wp-json\/wp\/v2\/posts\/7015"}],"collection":[{"href":"https:\/\/therapytoronto.ca\/news\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/therapytoronto.ca\/news\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/therapytoronto.ca\/news\/wp-json\/wp\/v2\/users\/4"}],"replies":[{"embeddable":true,"href":"https:\/\/therapytoronto.ca\/news\/wp-json\/wp\/v2\/comments?post=7015"}],"version-history":[{"count":5,"href":"https:\/\/therapytoronto.ca\/news\/wp-json\/wp\/v2\/posts\/7015\/revisions"}],"predecessor-version":[{"id":7030,"href":"https:\/\/therapytoronto.ca\/news\/wp-json\/wp\/v2\/posts\/7015\/revisions\/7030"}],"wp:attachment":[{"href":"https:\/\/therapytoronto.ca\/news\/wp-json\/wp\/v2\/media?parent=7015"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/therapytoronto.ca\/news\/wp-json\/wp\/v2\/categories?post=7015"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/therapytoronto.ca\/news\/wp-json\/wp\/v2\/tags?post=7015"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}![\"Senior](\"http:\/\/www.therapytoronto.ca\/images\/blogpics\/SeniorCaretaker.jpg\"){kind=icon}
New research proves the validity of one of the most promising approaches for combating Alzheimer\u2019s disease (AD) with medicines that treat not just some of the symptoms, but actually stop or prevent the disease itself<\/strong>, scientists are reporting. The study, in the journal ACS Medicinal Chemistry Letters<\/em>, also identifies a potential new oral drug that the scientists say could lead the way.<\/p>\n