{"id":8893,"date":"2012-12-08T14:33:32","date_gmt":"2012-12-08T19:33:32","guid":{"rendered":"http:\/\/therapytoronto.ca\/news\/?p=8893"},"modified":"2012-12-08T18:07:57","modified_gmt":"2012-12-08T23:07:57","slug":"study-examines-role-of-inflammation-in-chronic-fatigue-syndrome","status":"publish","type":"post","link":"https:\/\/therapytoronto.ca\/news\/2012\/12\/study-examines-role-of-inflammation-in-chronic-fatigue-syndrome\/","title":{"rendered":"Study examines role of inflammation in chronic fatigue syndrome"},"content":{"rendered":"<p>From the <em>Journal of Psychotherapy and Psychosomatics <\/em>press release via AlphaGalileo:<\/p>\n<blockquote><p><img loading=\"lazy\" class=\"alignright\" title=\"medical team\" src=\"http:\/\/therapytoronto.ca\/images\/blogpics\/medical_team.jpg\" alt=\"medical team\" width=\"290\" height=\"235\" \/>A new study published in the current issue of <em>Psychotherapy and Psychosomatics<\/em> has <strong>examined the role of inflammation in chronic fatigue syndrome<\/strong>, a disorder that affects many people and does not seem to have an explanation that is likely to yield satisfactory treatment.<\/p>\n<p>Depression is an inflammatory disorder while many authors declare myalgic encephalomyelitis\/chronic fatigue syndrome (ME\/CFS) to be a functional disorder. <strong>The aim of the present study was to compare inflammatory and cell-mediated immune (CMI) responses between depression and ME\/CFS<\/strong>. The investigators measured two proinflammatory cytokines (PICs) in plasma, interleukin-1 (IL-1) and tumor necrosis factor-? (TNF-?), with enzyme-linked immunosorbent assays, and serum neopterin with a radioimmunoassay in controls, ME\/CFS and depressive patients.<\/p>\n<p><strong>Plasma PICs were significantly higher in ME\/CFS than in depression and higher in both patient groups than in controls<\/strong>. Increased PIC levels in depression were attributable to the presence of fatigue and physio-somatic symptoms. Serum neopterin did not differ significantly between depression and ME\/CFS but was higher in both patient groups than in controls.<\/p>\n<p>The significant positive correlations between neopterin and either IL-1 or TNF-? were significantly greater in depression than in ME\/CFS. <strong>Since PICs cause depression-like behaviors and fatigue\/malaise, the investigators suggest that inflammation may play a role in the pathophysiology of ME\/CFS and depression<\/strong>. Increased neopterin also seems to contribute to the pathophysiology of both disorders. This study has detected a shared \u2018pathway phenotype\u2019, i.e. disorders in inflammatory and CMI pathways, which underpins both ME\/CFS and depression and, therefore, may explain the co-occurrence of both disorders.<\/p>\n<p>ME\/CFS and depression are discriminated from each other by increased PICs in ME\/CFS and differences in the immune cell communication networks.<\/p><\/blockquote>\n<!-- AddThis Advanced Settings generic via filter on the_content --><!-- AddThis Share Buttons generic via filter on the_content -->","protected":false},"excerpt":{"rendered":"<p>From the Journal of Psychotherapy and Psychosomatics press release via AlphaGalileo: A new study published in the current issue of Psychotherapy and Psychosomatics has examined the role of inflammation in&#8230; <a class=\"read-more-link\" href=\"https:\/\/therapytoronto.ca\/news\/2012\/12\/study-examines-role-of-inflammation-in-chronic-fatigue-syndrome\/\">Read more &raquo;<\/a><!-- AddThis Advanced Settings generic via filter on get_the_excerpt --><!-- AddThis Share Buttons generic via filter on get_the_excerpt --><\/p>\n","protected":false},"author":4,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":[],"categories":[5,10],"tags":[14,191],"_links":{"self":[{"href":"https:\/\/therapytoronto.ca\/news\/wp-json\/wp\/v2\/posts\/8893"}],"collection":[{"href":"https:\/\/therapytoronto.ca\/news\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/therapytoronto.ca\/news\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/therapytoronto.ca\/news\/wp-json\/wp\/v2\/users\/4"}],"replies":[{"embeddable":true,"href":"https:\/\/therapytoronto.ca\/news\/wp-json\/wp\/v2\/comments?post=8893"}],"version-history":[{"count":3,"href":"https:\/\/therapytoronto.ca\/news\/wp-json\/wp\/v2\/posts\/8893\/revisions"}],"predecessor-version":[{"id":8989,"href":"https:\/\/therapytoronto.ca\/news\/wp-json\/wp\/v2\/posts\/8893\/revisions\/8989"}],"wp:attachment":[{"href":"https:\/\/therapytoronto.ca\/news\/wp-json\/wp\/v2\/media?parent=8893"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/therapytoronto.ca\/news\/wp-json\/wp\/v2\/categories?post=8893"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/therapytoronto.ca\/news\/wp-json\/wp\/v2\/tags?post=8893"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}