1. New insights into why sleep is good for our memory

    November 22, 2017 by Ashley

    From the University of York press release:

    Researchers at the University of York have shed new light on sleep’s vital role in helping us make the most of our memory.

    Sleep, they show, helps us to use our memory in the most flexible and adaptable manner possible by strengthening new and old versions of the same memory to similar extents.

    The researchers also demonstrate that when a memory is retrieved — when we remember something — it is updated with new information present at the time of remembering. The brain appears not to ‘overwrite’ the old version of the memory, but instead generates and stores multiple (new and old) versions of the same experience.

    The results of the research, carried out at York’s Sleep, Language and Memory (SLAM) Laboratory, are presented in the journal Cortex today.

    Lead researcher Dr Scott Cairney of York’s Department of Psychology said: “Previous studies have shown sleep’s importance for memory. Our research takes this a step further by demonstrating that sleep strengthens both old and new versions of an experience, helping us to use our memories adaptively.

    “In this way, sleep is allowing us to use our memory in the most efficient way possible, enabling us to update our knowledge of the world and to adapt our memories for future experiences.”

    In the study, two groups of subjects learned the location of words on a computer screen. In a test phase, participants were presented with each of the words in the centre of the screen and had to indicate where they thought they belonged.

    One group then slept for 90 minutes while a second group remained awake before each group repeated the test. In both groups, the location recalled at the second test was closer to that recalled at the first test than to the originally-learned location, indicating that memory updating had taken place and new memory traces had been formed.

    However, when comparing the sleep and wake groups directly, the locations recalled by the sleep group were closer in distance to both the updated location (i.e. previously retrieved) and the original location, suggesting that sleep had strengthened both the new and old version of the memory.

    Corresponding author Professor Gareth Gaskell of York’s Department of Psychology said: “Our study reveals that sleep has a protective effect on memory and facilitates the adaptive updating of memories.

    “For the sleep group, we found that sleep strengthened both their memory of the original location as well as the new location. In this way, we were able to demonstrate that sleep benefits all the multiple representations of the same experience in our brain.”

    The researchers point out that although this process helps us by allowing our memories to adapt to changes in the world around us, it can also hinder us by incorporating incorrect information into our memory stores. Over time, our memory will draw on both accurate and inaccurate versions of the same experience, causing distortions in how we remember previous events.

    The study builds on a research model created by Ken Paller, Professor of Psychology at Northwestern University, USA, an eminent researcher in the field of memory and a co-author on this study.

    The research was funded by the Economic and Social Research Council (ESRC).


  2. Study suggests cognitive training enhanced innovative thinking and brain networks in older adults

    by Ashley

    From the Center for BrainHealth press release:

    Researchers at the Center for BrainHealth at UT Dallas have demonstrated in a pilot study that cognitive training improves innovative thinking, along with corresponding positive brain changes, in healthy adults over the age of 55.

    The study, published recently in Frontiers in Aging Neuroscience, reveals that a specific strategic cognitive training program enhanced innovation in healthy adults. Performance was measured by an individual’s ability to synthesize complex information and generate a multitude of high-level interpretations.

    “Middle-age to older adults should feel empowered that, in many circumstances, they can reverse decline and improve innovative thinking,” said Dr. Sandra Bond Chapman, Center for BrainHealth founder and chief director and lead author of the study. “Innovative cognition — the kind of thinking that reinforces and preserves complex decision-making, intellect and psychological well-being — does not need to decline with age. This study reveals that cognitive training may help enhance cognitive capacities and build resilience against decline in healthy older adults.”

    The SMART program — Strategic Memory Advanced Reasoning Training — was developed at the Center for BrainHealth. It focuses on learning strategies that foster attention, reasoning and broad-based perspective-taking.

    Center for BrainHealth researchers conducted a randomized pilot trial and compared the effect of SMART to aerobic exercise training (known to be good for brain health) and control subjects on innovative cognition. The SMART program was conducted one hour per week for 12 weeks with 2 hours of homework each week. The 58 participants were assessed at baseline-, mid- and post-training using innovative cognition measures and functional MRI, a brain scanning technology that reveals brain activity.

    “In addition to evaluating the effects of the cognitive training, this study also provided an opportunity to test a reliable assessment tool to measure innovative cognition, which has been relatively neglected due to the complexity of quantifying innovative thinking,” Chapman said.

    The 19 participants in the cognitive reasoning training group (SMART) showed significant gains pre- to post-training in high-quality innovation performance, improving their performance by an average of 27 percent from baseline to mid- and post-training periods on innovative cognition measures. The physical exercise and control groups did not show improvement. These positive gains in the reasoning training group corresponded to increased connectivity among brain cells in the central executive network of the brain, an area responsible for innovative thinking.

    “Advances in the field of MRI are allowing us to measure different aspects of brain function,” said Dr. Sina Aslan, an imaging specialist at the Center for BrainHealth. “Through this research, we are able to see that higher activity in the central executive network corresponded to improved innovation. These findings suggest that staying mentally active not only mitigates cognitive decline, but also has the potential to restore creative thinking, which is typically lost with aging.”

    While further research is needed to establish how to ensure the benefit persists, Chapman is encouraged by the results.

    “Reasoning training offers a promising cost-effective intervention to enhance innovative cognition — one of the most valued capacities and fruitful outputs of the human mind at any age.”

    The work was supported by a grant from the National Institute of Health and by grants from the T. Boone Pickens Foundation, the Lyda Hill Foundation and Dee Wyly Distinguished University Endowment.


  3. Study suggests reasons why head and face pain causes more suffering

    by Ashley

    From the Duke University press release:

    Hate headaches? The distress you feel is not all in your — well, head. People consistently rate pain of the head, face, eyeballs, ears and teeth as more disruptive, and more emotionally draining, than pain elsewhere in the body.

    Duke University scientists have discovered how the brain’s wiring makes us suffer more from head and face pain. The answer may lie not just in what is reported to us by the five senses, but in how that sensation makes us feel emotionally.

    The team found that sensory neurons that serve the head and face are wired directly into one of the brain’s principal emotional signaling hubs. Sensory neurons elsewhere in the body are also connected to this hub, but only indirectly.

    The results may pave the way toward more effective treatments for pain mediated by the craniofacial nerve, such as chronic headaches and neuropathic face pain.

    “Usually doctors focus on treating the sensation of pain, but this shows the we really need to treat the emotional aspects of pain as well,” said Fan Wang, a professor of neurobiology and cell biology at Duke, and senior author of the study. The results appear online Nov. 13 in Nature Neuroscience.

    Pain signals from the head versus those from the body are carried to the brain through two different groups of sensory neurons, and it is possible that neurons from the head are simply more sensitive to pain than neurons from the body.

    But differences in sensitivity would not explain the greater fear and emotional suffering that patients experience in response to head-face pain than body pain, Wang said.

    Personal accounts of greater fear and suffering are backed up by functional Magnetic Resonance Imaging (fMRI), which shows greater activity in the amygdala — a region of the brain involved in emotional experiences — in response to head pain than in response to body pain.

    “There has been this observation in human studies that pain in the head and face seems to activate the emotional system more extensively,” Wang said. “But the underlying mechanisms remained unclear.”

    To examine the neural circuitry underlying the two types of pain, Wang and her team tracked brain activity in mice after irritating either a paw or the face. They found that irritating the face led to higher activity in the brain’s parabrachial nucleus (PBL), a region that is directly wired into the brain’s instinctive and emotional centers.

    Then they used methods based on a novel technology recently pioneered by Wang’s group, called CANE, to pinpoint the sources of neurons that caused this elevated PBL activity.

    “It was a eureka moment because the body neurons only have this indirect pathway to the PBL, whereas the head and face neurons, in addition to this indirect pathway, also have a direct input,” Wang said. “This could explain why you have stronger activation in the amygdala and the brain’s emotional centers from head and face pain.”

    Further experiments showed that activating this pathway prompted face pain, while silencing the pathway reduced it.

    “We have the first biological explanation for why this type of pain can be so much more emotionally taxing than others,” said Wolfgang Liedtke, a professor of neurology at Duke University Medical Center and a co-author on Wang’s paper, who is also treating patients with head- and face-pain. “This will open the door toward not only a more profound understanding of chronic head and face pain, but also toward translating this insight into treatments that will benefit people.”

    Chronic head-face pain such cluster headaches and trigeminal neuralgia can become so severe that patients seek surgical solutions, including severing the known neural pathways that carry pain signals from the head and face to the hindbrain. But a substantial number of patients continue to suffer, even after these invasive measures.

    “Some of the most debilitating forms of pain occur in the head regions, such as migraine,” said Qiufu Ma, a professor of neurobiology at Harvard Medical School, who was not involved in the study. “The discovery of this direct pain pathway might provide an explanation why facial pain is more severe and more unpleasant.”

    Liedtke said targeting the neural pathway identified here can be a new approach toward developing innovative treatments for this devastating head and face pain.


  4. Injury from contact sport has harmful, though temporary effect on memory

    by Ashley

    From the McMaster University press release:

    McMaster University neuroscientists studying sports-related head injuries have found that it takes less than a full concussion to cause memory loss, possibly because even mild trauma can interrupt the production of new neurons in a region of the brain responsible for memory.

    Though such losses are temporary, the findings raise questions about the long-term effects of repeated injuries and the academic performance of student athletes.

    The researchers spent months following dozens of athletes involved in high-contact sports such as rugby and football, and believe that concussions and repetitive impact can interrupt neurogenesis — or the creation of new neurons — in the hippocampus, a vulnerable region of the brain critical to memory.

    The findings were presented today (Tuesday, November 14th) at the Society for Neuroscience’s annual conference, Neuroscience 2017, in Washington D.C.

    “Not only are newborn neurons critical for memory, but they are also involved in mood and anxiety,” explains Melissa McCradden, a neuroscience postdoctoral fellow at McMaster University who conducted the work. “We believe these results may help explain why so many athletes experience difficulties with mood and anxiety in addition to memory problems.”

    For the study, researchers administered memory tests and assessed different types of athletes in two blocks over the course of two years. In the first block, they compared athletes who had suffered a concussion, uninjured athletes who played the same sport, same-sport athletes with musculoskeletal injuries, and healthy athletes who acted as a control group.

    Concussed athletes performed worse on the memory assessment called a mnemonic similarity test (MST), which evaluates a person’s ability to distinguish between images that are new, previously presented, or very similar to images previously presented.

    In the second study, rugby players were given the MST before the season started, halfway through the season, and one month after their last game. Scores for injured and uninjured athletes alike dropped midseason, compared to preseason scores, but recovered by the postseason assessment.

    Both concussed and non-concussed players showed a significant improvement in their performance on the test after a reprieve from their sport.

    For the concussed athletes, this occurred after being medically cleared to return to full practice and competition. For the rugby players, they improved after approximately a month away from the sport.

    If neurogenesis is negatively affected by concussion, researchers say, exercise could be an important tool in the recovery process, since it is known to promote the production of neurons. A growing body of new research suggests that gentle exercise which is introduced before a concussed patient is fully symptom free, is beneficial.

    “The important message here is that the brain does recover from injury after a period of reprieve,” says McCradden. “There is a tremendous potential for the brain to heal itself.”


  5. Study suggests declining sense of smell may help identify patients with mild cognitive impairment

    November 21, 2017 by Ashley

    From the Columbia University Medical Center press release:

    Researchers at Columbia University Medical Center (CUMC) and the New York State Psychiatric Institute (NYSPI) may have discovered a way to use a patient’s sense of smell to treat Alzheimer’s disease before it ever develops. Having an impaired sense of smell is recognized as one of the early signs of cognitive decline, before the clinical onset of Alzheimer’s disease. The researchers at CUMC and NYSPI have found a way to use that effect to determine if patients with mild cognitive impairment may respond to cholinesterase inhibitor drugs to treat Alzheimer’s disease.

    The findings were published online this week in the Journal of Alzheimer’s Disease.

    Cholinesterase inhibitors, such as donepezil, enhance cholinergic function by increasing the transmission of the neurotransmitter acetylcholine in the brain. Cholinergic function is impaired in individuals with Alzheimer’s disease. Cholinesterase inhibitors, which block an enzyme that breaks down acetylcholine, have shown some effectiveness in improving the cognitive symptoms of Alzheimer’s disease. However, they have not been proven effective as a treatment for individuals with mild cognitive impairment (MCI), a condition that markedly increases the risk of Alzheimer’s disease.

    “We know that cholinesterase inhibitors can make a difference for Alzheimer’s patients, so we wanted to find out if we could identify patients at risk for Alzheimer’s who might also benefit from this treatment,” said D.P. Devanand, MBBS, MD, professor of psychiatry, scientist in the Gertrude H. Sergievsky Center at CUMC, and co-director of the Memory Disorders Clinic and the Late Life Depression Clinic at NYSPI. “Since odor identification tests have been shown to predict progression to Alzheimer’s, we hypothesized that these tests would also allow us to discover which patients with MCI would be more likely to improve with donepezil treatment.”

    In this year-long study, 37 participants with MCI underwent odor identification testing with the University of Pennsylvania Smell Identification Test (UPSIT). The test was administered before and after using an atropine nasal spray that blocks cholinergic transmission.

    The patients were then treated with donepezil for 52 weeks, and were periodically reevaluated with the UPSIT and with memory and cognitive function tests. Those who had a greater decline in UPSIT scores, indicating greater cholinergic deficits in the brain, after using the anticholinergic nasal spray test saw greater cognitive improvement with donepezil.

    In addition, short-term improvement in odor identification from baseline to eight weeks tended to predict longer-term cognitive improvement with donepezil treatment over one year.

    “These results, particularly if replicated in larger populations, suggest that these simple inexpensive strategies have the potential to improve the selection of patients with mild cognitive impairment who are likely to benefit from treatment with cholinesterase inhibitors like donepezil,” said Dr. Devanand.


  6. Study suggests biomarker may predict early Alzheimer’s disease

    November 20, 2017 by Ashley

    From the Sanford-Burnham Prebys Medical Discovery Institute press release:

    Researchers at Sanford Burnham Prebys Medical Discovery Institute (SBP) have identified a peptide that could lead to the early detection of Alzheimer’s disease (AD). The discovery, published in Nature Communications, may also provide a means of homing drugs to diseased areas of the brain to treat AD, Parkinson’s disease, as well as glioblastoma, brain injuries and stroke.

    “Our goal was to find a new biomarker for AD,” says Aman Mann, Ph.D., research assistant professor at SBP who shares the lead authorship of the study with Pablo Scodeller, Ph.D., a postdoctoral researcher at SBP. “We have identified a peptide (DAG) that recognizes a protein that is elevated in the brain blood vessels of AD mice and human patients. The DAG target, connective tissue growth factor (CTGF) appears in the AD brain before amyloid plaques, the pathological hallmark of AD.”

    “CTGF is a protein that is made in the brain in response to inflammation and tissue repair,” explains Mann. “Our finding that connects elevated levels of CTGF with AD is consistent with the growing body of evidence suggesting that inflammation plays an important role in the development of AD.”

    The research team identified the DAG peptide using in vivo phage display screening at different stages of AD development in a mouse model. In young AD mice, DAG detected the earliest stage of the disease. If the early appearance of the DAG target holds true in humans, it would mean that DAG could be used as a tool to identify patients at early, pre-symptomatic stages of the disease when treatments already available may still be effective.

    “Importantly, we showed that DAG binds to cells and brain from AD human patients in a CTGF-dependent manner” says Mann. “This is consistent with an earlier report of high CTGF expression in the brains of AD patients.”

    “Our findings show that endothelial cells, the cells that form the inner lining of blood vessels, bind our DAG peptide in the parts of the mouse brain affected by the disease,” says Erkki Ruoslahti, M.D., Ph.D., distinguished professor at SBP and senior author of the paper. “This is very significant because the endothelial cells are readily accessible for probes injected into the blood stream, whereas other types of cells in the brain are behind a protective wall called the blood-brain barrier. The change in AD blood vessels gives us an opportunity to create a diagnostic method that can detect AD at the earliest stage possible.

    “But first we need to develop an imaging platform for the technology, using MRI or PET scans to differentiate live AD mice from normal mice. Once that’s done successfully, we can focus on humans,” adds Ruoslahti.

    “As our research progresses we also foresee CTGF as a potential therapeutic target that is unrelated to amyloid beta (Aß), the toxic protein that creates brain plaques,” says Ruoslahti. “Given the number of failed clinical studies that have sought to treat AD patients by targeting Aß, it’s clear that treatments will need to be given earlier — before amyloid plaques appear — or have to target entirely different pathways.

    DAG has the potential to fill both roles — identifying at risk individuals prior to overt signs of AD and targeted delivery of drugs to diseased areas of the brain. Perhaps CTGF itself can be a drug target in AD and other brain disorders linked to inflammation. We’ll just have to learn more about its role in these diseases.”


  7. Researchers design social mobile gaming that boosts rehabilitation for physically impaired patients

    November 18, 2017 by Ashley

    From the Imperial College London press release:

    The researchers from Imperial have designed a video game called Balloon Buddies, which is a tool that enables those recovering from conditions such as a stroke to engage and play together with healthy volunteers such as therapists and family members as a form of rehabilitation.

    Balloon Buddies is designed to level the playing field by allowing healthy participants to support the less abled player. The researchers have shown that this type of collaboration makes it more rewarding for the less-abled partner, more challenging for the better partner, and overall more fun for both, as they have to continuously work together to score points.

    The team have trialled Balloon Buddies by getting patients to play it on their own in single player mode and then partnered with healthy volunteers during dual player gameplay. They found that the performance of the patient was boosted when they played with a healthy volunteer, compared to if they were playing the game on their own. In addition, they found that the poorer a patient’s single player performance was, the greater the improvement seen when they played with another during dual-player mode.

    These findings published today in the Journal of NeuroEngineering and Rehabilitation (JNER), suggest that by increasing engagement with healthy volunteers, compared to playing alone, patients may be more likely to increase the effort they put into training, which could ultimately lead to greater gains in physical performance.

    While the pilot study was limited to 16 patients and 32 healthy participants playing in 16 pairs, the researchers believe this form of rehabilitation through gaming may be beneficial to patients recovering from other illnesses such as musculoskeletal injuries, arthritis, and cerebral palsy. The researchers are aiming to further develop the game alongside new multiplayer concepts and show that it can be used in different settings including patients training with their therapist or with other patients, in community centres or even remotely at home.

    Dr Michael Mace, lead author from the Department of Bioengineering at Imperial College London, said: “Video games are a great way of providing repetitive exercise to help patients recover from debilitating illnesses. However, most games are designed for users to play on their own, which can actually discourage and isolate many patients. We developed the Balloon Buddy game to enable patients to train with their friends, family or caregivers in a collaborative and playful manner. The technology is still being developed, but we have shown that playing jointly with another individual may lead to increased engagement and better outcomes for patients.”

    Balloon Buddies uses animation, sounds, and vibration-feedback, similar to conventional video games. It requires users to balance a ball on a beam, which is lifted at each of its ends by balloons controlled by the players. The main aim of the game is for the players to vary the height of the beam so that the ball collides with moving targets in order to collect points. Players are also required to work together to keep the beam horizontal so that the ball doesn’t roll off the platform. It is played with a wireless handgrip called GripAble, enabling people with arm weakness to control video games on any standard tablet device.

    In the study, the researchers tested the game on 16 patients who had arm weakness following a stroke with a healthy volunteer over three months at Charing Cross Hospital, which is part of Imperial College Healthcare NHS Trust, in 2016. Previously, the game was also tested on 16 healthy pairs with different baseline abilities.

    The team will now carry out a larger study to examine whether the game leads to more efficient learning and to examine if patients are more motivated to train for longer periods. They will also explore social implications of interaction such as the effect of patients playing with a relative versus a stranger.


  8. Study suggests exercise may be beneficial to mental health regimen

    November 17, 2017 by Ashley

    From the Michigan State University press release:

    More mental health providers may want to take a closer look at including exercise in their patients’ treatment plans, a new study suggests.

    Michigan State University and University of Michigan researchers asked 295 patients receiving treatment at a mental health clinic whether they wanted to be more physically active and if exercise helped improve their mood and anxiety. They also asked if patients wanted their therapist to help them become more active.

    Eighty-five percent said they wanted to exercise more and over 80 percent believed exercise helped improve their moods and anxiety much of the time. Almost half expressed interest in a one-time discussion, with many participants also wanting ongoing advice about physical activity with their mental health provider.

    The study is now published in the journal General Hospital Psychiatry.

    Physical activity has been shown to be effective in alleviating mild to moderate depression and anxiety,” said Carol Janney, lead author of the study and an MSU assistant professor of epidemiology. “Current physical activity guidelines advise at least 30 minutes, five days a week to promote mental and physical health, yet many of those surveyed weren’t meeting these recommendations.”

    More than half of the participants said their mood limited their ability to exercise, which Janney said provides an opportunity for physicians and therapists in clinics to offer additional support.

    “Offering physical activity programs inside the mental health clinics may be one of many patient-centered approaches that can improve the mental and physical health of patients,” Janney said.

    Marcia Valenstein, senior author and professor emeritus in psychiatry at U-M, agreed.

    “Mental health treatment programs need to partner with fitness programs to support their patients’ willingness to exercise more,” she said. “This support might come from integrating personal trainers into mental health clinics or having strong partnerships with the YMCA or other community recreational facilities.”

    Both Valenstein and Janney said that psychiatrists and other providers might discuss with patients the general need to exercise, but few actually sit down with patients and create a comprehensive exercise plan for them or regularly make sure they are adhering to a specific goal.

    “Mental health providers such as psychiatrists and therapists may not have the necessary training to prescribe physical activity as part of their mental health practice,” Janney said. “But by teaming up with certified personal trainers or other exercise programs, it may help them prescribe or offer more recommendations for physical activity in the clinic setting.”

    Results also showed that over half of the patients surveyed showed interest in getting help from a personal trainer and were willing to pay a bit extra, but that the topic of physical activity was rarely discussed by their physician.

    “This is a missed opportunity,” Valenstein said. “If we can make it easier for both therapists and their patients to have easier access to physical activity services, then we are likely to help more patients reduce their depression and anxiety.”

    Once the effectiveness of this approach is proven, she added, health insurers might consider moving in the direction of covering services that help people exercise.

    “Several insurers already do this for diabetes prevention, so it’s not out of the question.”


  9. Researchers develop way to stimulate formation of new neural connections in adult brain

    November 16, 2017 by Ashley

    From the University of Idaho press release:

    A team led by University of Idaho scientists has found a way to stimulate formation of new neural connections in the adult brain in a study that could eventually help humans fend off memory loss, brain trauma and other ailments in the central nervous system.

    Peter G. Fuerst, an associate professor in the College of Science’s Department of Biological Sciences and WWAMI Medical Education Program, and a team that included lead author doctoral student Aaron Simmons, were able to stimulate growth of new neural connections in mice that are needed to connect the cells into neural circuits. Their study, which included scientists from the University of Louisville and University of Puerto Rico-Humacao, is titled “DSCAM-Mediated Control of Dendritic and Axonal Arbor Outgrowth Enforces Tiling and Inhibits Synaptic Plasticity.” It was published today in the Journal Proceedings of the National Academy of Sciences.

    “The paper is a study into factors that prevent adult neurons from making new connections,” Fuerst said. “Regulation of this process is important to prevent several disorders, such as autism, but is also related to the inability of the adult nervous system to readily recover from damage.”

    Researchers studied a cell population that has the unusual ability to make new connections into adulthood, but under normal conditions does not grow the needed axons or dendrites. The team was able to genetically manipulate the cell population in the mice to induce axon and dendrite outgrowth. They found this induced the formation of stable, functional connections with new cells.

    “The idea is that one could stimulate the nervous system to make new connections if there was some kind of trauma,” Fuerst said. “Maybe this is the way to reactivate the cell to build those new connections that we can take advantage of clinically.”

    Their efforts included research through the regional WWAMI Medical Education Program at the University of Washington and could have wide ramifications for other adult neurological conditions that prevent human brains from making those needed connections as an adult.

    “In children in early development it’s very easy to make new connections, but adults lose that ability, and we want to see why that is,” he said.

    The genetic manipulation used in mice as part of the study wouldn’t work in humans. Instead, Fuerst and his team would next like to test small-molecule drugs that regulate these central nervous system processes — currently used to combat cancer in humans — to see if they can help the nervous system make new connections in mice.

    “These contributions by Peter and his team right here at the University of Idaho are helping advance global neurological research,” said Janet Nelson, vice president for research and economic development. “I’m excited by the potential impact of this research on the understanding of the brain and in advancing human health.”


  10. Study suggests optimists and happy people are healthier overall

    November 14, 2017 by Ashley

    From the University of Michigan press release:

    Research shows that optimists and happy people are healthier overall, enjoying lower blood pressure and less depression and anxiety, among other measures.

    However, data on the effect of weight and Body Mass Index on physical and mental health are rare — especially among college students, who suffer high rates of anxiety and depression and often neglect physical self-care and exercise.

    To that end, researchers from the University of Michigan and Fudan University in China set out to learn the extent to which BMI and positive outlook affect the physical and mental health of college students in China’s Fudan University.

    They found that a positive outlook and BMI both contributed significantly to good health, said Weiyun Chen, associate professor of health and fitness at the U-M School of Kinesiology.

    Researchers asked 925 students to rate four indicators of psychological well-being: hope, gratitude, life satisfaction and subjective happiness. They also calculated students’ BMI based on self-reported body weight and height. To assess physical and mental health, researchers asked students various questions about their sleep quality and how often they felt healthy, energized, worthless, fidgety, anxious or depressed.

    Chen said that taken together, the four psychological variables and BMI accounted for 41 percent of the total variance in health. Individually, subjective happiness had the most significant impact, followed by hope, and then BMI.

    By themselves, gratitude and life satisfaction didn’t influence overall health. Also, interestingly, BMI was correlated with physical and overall health, but not with hope, gratitude, life satisfaction or mental health.

    In light of the intense academic pressure Chinese college students face, especially at elite institutions like Fudan, Chen said she was surprised by how many students rated themselves happy and healthy. This could point to China’s emphasis on well-being in schools.

    “They have structured, organized physical educations classes,” Chen said. “It’s not just fitness, it’s a variety of things so you can meet different people’s needs. They realized that emphasizing only academics isn’t good for overall health, and that they needed to emphasize the wellness part.”

    These numbers might look different for college students in the U.S., where two of three adults are overweight or obese, and 17 percent of youth ages 2-19 are considered obese, according to the CDC.

    By contrast, 714 Fudan students, or 77.2 percent, were classified as normal body weight, while only 83 students were overweight, and just 5 students were obese, with 123 students considered underweight.

    “Over the past 20 years, the United States has shrunk physical education in elementary school and in college,” Chen said. “In China, especially in the past decade, they have started to emphasize physical education, and they are taking a holistic, whole person approach.”

    Chen said the findings suggest that universities should creatively design wellness programs and centers that dynamically integrate body, mind and spirit into a seamless unit.

    The study has several limitations: all students were recruited from one university, and the results cannot be generalized; the research design prevented establishing causal effects; and the study did not account for gender differences.